What is PEA?
Palmitoylethanolamide (PEA) is a biologically active, endogenous lipid that is widely distributed throughout the body's tissues and is synthesized on demand. (Gabrielsson 2016) It was first isolated in 1957 as an anti-inflammatory component in egg yolks and is found in many foods. PEA has been studied extensively for its anti-inflammatory, neuroprotective and analgesic properties since the 1970's.* (Hesselink 2013)
PEA plays a key role in maintaining homeostasis by regulating many physiological reactions associated with injury, illness and inflammation.* Some chronic conditions can result in a hyper immune response that involves excessive activation of microglial and mast cells, while simultaneously depleting PEA, which acts as a modulator for these cells. Excessive activation of these non-neuronal cells has been shown to maintain chronic inflammation and result in neuro-degeneration.* Increased levels of PEA have been shown to normalize the immune response by down regulating mast and microglial cell activity, thereby decreasing neuro-inflammation and neuron loss.* (Raso 2014)
PEA - Clinically Shown to Reduce Pain
In recent years a growing number of clinical studies have confirmed the pain relieving and anti-inflammatory properties of PEA.*
A meta-analysis involving a total of 1484 chronic pain patients, found those treated with PEA reported pain levels an average of 2.7 points lower than the control groups after 60 days.* (Paladini 2016)
Luteolin is a potent bioflavonoid with antioxidant and anti-inflammatory properties.* Like PEA, luteolin has several mechanisms of action. It inhibits mast cells, as well as mast cell-dependent T cell activation.* (Theoharides 2018) In addition, it modulates microglial activation and inhibits pro-inflammatory cytokine production.* (Dirscherl 2010) It also acts on GABA and opioid receptors in the spinal cord.* (Li 2015)
The Synergistic Combination of PEA and Luteolin*
When combined, PEA and luteolin show enhanced anti-inflammatory, anti-oxidant and neuroprotective properties.* Coadministration of PEA with luteolin has been shown to decrease mast cell activation significantly more than PEA or luteolin alone.* This combination has been shown to reduce pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6) and chemokines (MIP-1 alpha, MIP-2) significantly more than PEA or luteolin alone.* Additionally, PEA with luteolin was shown to reduce oxidative and nitrosative damage more effectively than PEA or luteolin alone.* (Impellizzeri 2018)
Due to these and other immune-regulating properties, the PEA /luteolin combination shows exceptional promise as part of a therapeutic strategy for promoting a healthy inflammatory response and supporting healthy nervous and immune systems.*
PEA occurs naturally in the body and in many foods. No side effects have been reported with PEA use, even at the highest doses. (Gabrielsson 2016)
The recommended daily dose of Mirica® contains the equivalent amount of luteolin as found in one artichoke. At this dose, no adverse effects have been reported.
For those taking Mirica® for general immune support and minor aches and pains, 2-3 capsules per day is recommended. Others will need to start with the maximum dose of 5-6 capsules per day for at least 60 days to asses if Mirica® is right for them. At that point, the daily dosage may be reduced gradually until the appropriate maintenance dose is determined. Most people will begin to experience benefits in the first week and will continue to see improvement over the first 2-3 months.**
Starting Dose: Take 2-3 capsules in the morning and 2-3 capsules in the evening with food for at least 4 weeks.
Maintenance Dose: Take 1- 2 capsules with food twice daily.
At Young Nutraceuticals, every product is made from the purest food and herb based ingredients and nothing else.
Mirica® is gluten free and contains no binders, fillers or preservatives. Mirica® is made in a cGMP and FDA registered facility in the USA and is tested multiple times by an independent lab.