Mechanism of Action

Pictured: Mast cell releasing histamine

Palmitoylethanolamide (PEA) is a biologically active, endogenous lipid that is widely distributed throughout the body's tissues and is produced on demand. It was first isolated from egg yolks in 1957 as an anti-inflammatory component and has been studied extensively in recent years.*

PEA plays a key role in maintaining homeostasis by regulating many physiological reactions associated with pain and inflammation.* Some chronic conditions can result in a hyper-immune response involving microglia, mast cells and astrocytes. Excessive activation of these satellite, non-neuronal cells has been shown to maintain pain, inflammation and result in neurodegeneration. PEA appears to act as a protective endogenous mediator that is produced “on demand” during inflammatory and neurodegenerative conditions to counter inflammation, pain, and neuronal damage.* Multiple studies have demonstrated that endogenous PEA increases in the brain and spinal cord following neuropathic pain induction, injury and other related conditions.* Microglia, astrocytes and mast cells are the most recognized cellular targets of PEA. PEA has been shown to down-modulate these cells and reduce neuropathic pain in a number of experimental models and in human clinical trials.*

Pictured: Microglial cell 

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